Teoreler is a first of a kind web-based application featuring physiologically based pharmacokinetic (PBPK) models. PBPK models play a crucial role in the drug development process. PBPK models combine drug physicochemical properties, anatomical and physiological features of any given species and in vitro experimental data to simulate drug plasma concentrations. Some of the key features of PBPK models include:

  1. Simulate/predict drug pharmacokinetics across various organs and tissues
  2. Estimate optimal doses and dosing regimens for any route of administration
  3. Inform clinical study design in any target population
  4. Predict complex drug-drug interaction scenarios that are difficult to conduct using clinical scenarios

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Pharmacokinetics (PK) is a branch of pharmacology that studies the movement of an administered drug/xenobiotic in any given species. A certain amount of drug is generally required for a drug to have a therapeutic effect at the site of action (e.g. for the antibiotics to work at an infected area), which is measured in concentration (amount of drug per unit volume of blood/plasma). This is termed as minimum effective concentration (MEC) or minimum inhibitory concentration (MIC).

The four major processes that take place once a drug is administered are:

  1. Absorption  - the pathway of the drug reaching the systemic circulation (blood)
  2. Distribution - the extent of drug disposition across various organs of the body
  3. Metabolism - breakdown of the xenobiotic by the body
  4. Elimination - the excretion of the xenobiotic from the body


We would like to thank the USERS of beta version for your support and feedback during the beta phase.
Your contribution has facilitated the development of this PBPK web application much faster and further.