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Dosing inputs

Dose inputs

✶ Sex

An option to select the sex of the simulated individual is provided. Default selected individual is Both. If Both is selected, and population (can be chosen from 'Other Inputs' tab) is 1, an average male or female by random is simulated, else the ratio of female to male is displayed for the simulated population.

✶ Population

This value dictates the size of the simulated population in the ongoing run, accepting a range from 1 to 100 individuals. A cap has been implemented to restrict the population to a maximum of 100 individuals.
Please note: It's important to highlight that when the population exceeds 1, the plasma plot displays a shared region representing the 5-95th percentile range, capturing any observed variations among the simulated individuals.

Human model only

✶ Age range

The user can define the age range for the population in these input fields. The age spans for the children and adult models are 2-18 years and 18-60 years, respectively. Linearly spaced age values, customized to the user-provided population range, will be generated within the specified age brackets.

Animal models only

Other Inputs for animals

✶ Strain

Users can select specific animal strains to account for weight variations, aiding in the tailored simulation of pharmacokinetics. Each strain is accompanied by an associated age range, delineating the lower and upper limits for age-related weight computations. If a value falls outside this range, the computation considers the respective lowest or highest age to determine the weights accurately. This feature facilitates precise customization of pharmacokinetic simulations based on the chosen animal strain and its corresponding age parameters.

✶ Age

The animal's age influences the weight applied in the model. Next to each strain, the initial age of the animal should be specified to calculate the weights appropriately. If the age falls outside the given range for a particular strain, the weights will be computed using the lowest or highest age from the provided range.
Please note: Age of the animal should be provided in weeks.

✶ Dose

Dose and its units can be provided in this section. The units reflected in the plots, tables and reports can also be selected from the 'Other Inputs' tab.

✶ Dosing interval

The time interval between subsequent doses should be provided here. If it is a single dose, please provide zero as the value. The units of time should be the same as 'Time units' parameter provided at the end of this tab.

✶ Repeats

The number of subsequent doses should be entered here. Only an integer should be entered here.

✶ End time

The end time of the dose is computed automatically using the inputs from dosing interval and dose repeats. This field cannot be edited by the user.

✶ Simulation time

The simulation time irrespective of the end time can be provided here. If the simulation time is less than end time, the simulation time will accommodate the value of end time.

✶ Time units

The units of time to display in plots and tables can be chosen by the user here.