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Elimination

Elimination inputs

The renal clearance is referred to the elimination from the kidneys in this model. The values and the appropriate units can be selected from the provided boxes.

Child model only

Users can utilize the provided checkbox to specify whether the input for renal clearance pertains to an adult. If the checkbox is selected, the system interprets the input as an adult value and subsequently calculates the corresponding renal clearance for children using the scaling equations of glomerular filtration rate and renal clearance provided by W.L.Hayton1 and Edginton et al.2 respectively.


References

  1. Hayton WL. Maturation and growth of renal function: dosing renally cleared drugs in children. AAPS PharmSci. 2000;2(1):E3. https://doi.org/10.1208/ps020103.
  2. Edginton AN, Schmitt W, Voith B, Willmann S. A mechanistic approach for the scaling of clearance in children. Clin Pharmacokinet. 2006;45(7):683-704. https://doi.org/10.2165/00003088-200645070-00004.