This value dictates the size of the simulated population in the ongoing run, accepting a range from 1 to 100 individuals. A cap has been implemented to restrict the population to a maximum of 100 individuals.
Please note: It's important to highlight that when the population exceeds 1, the plasma plot displays a shared region representing the 5-95th percentile range, capturing any observed variations among the simulated individuals.
✶ Target concentration
An optional argument to enter the target concentration is provided. If this value is not zero, a horizontal line in red on the plots is shown.
Please note: Any positive value other than '0.0' would display a horizontal target line in red. The units are same as plasma concentration and can be selected using the adjacent box.
✶ Concentration units
Two concentration units are provided in the model for display - mg/L (or) μg/mL and ng/mL and are reflected in plots and tables.
Human model only
✶ Clinical study year
The average population tends to vary every few years. Therefore, the model has an option to select the appropriate year during which the clinical study was performed. This way, the available population nearest to the study year is used for simulation. By default, the latest year is considered.
✶ Age range
The user can define the age range for the population in these input fields. The age spans for the children and adult models are 2-18 years and 18-60 years, respectively. Linearly spaced age values, customized to the user-provided population range, will be generated within the specified age brackets.
Animal models only
Users can select specific animal strains to account for weight variations, aiding in the tailored simulation of pharmacokinetics. Each strain is accompanied by an associated age range, delineating the lower and upper limits for age-related weight computations. If a value falls outside this range, the computation considers the respective lowest or highest age to determine the weights accurately. This feature facilitates precise customization of pharmacokinetic simulations based on the chosen animal strain and its corresponding age parameters.
The animal's age influences the weight applied in the model. Next to each strain, the age range of the animal is specified to calculate the weights appropriately. If the age falls outside the given range, the weights will be computed using the lowest or highest age from the provided range.
Please note: Age of the animal should be provided in weeks.
The accuracy of dose predictions depends on the quality of the input data. Occasionally, discrepancies between observed and simulated data may arise due to limitations in in vitro-in vivo extrapolations. In such instances, adjustments to certain factors are necessary to align model simulations more closely with observed data. To facilitate this fine-tuning process, users have the option to adjust relevant parameters, including absorption rate, tissue-to-plasma ratios (utilizing a distribution scalar for consistency across organs and tissues), and clearance (both apparent and intrinsic), using scalar values in the provided boxes. Default value is 1. These scalars multiply the relevant process(es) by the given value.
Please note: If any of the scalars are set to zero or less, the model would automatically set the values to 1 to avoid errors.