Optional inputs
✶ Population
This number would determine the number of individuals or the population simulated in the current run. A number between 1 and 100 is accepted by
the model. A cap has been introduced to limit the population to 100 individuals.
Please note: If the population is greater than 1, the plasma plot showed a shared region representing the 5-95th percentile region, if any
variation is observed between the simulated individuals.
✶ Target concentration
An optional argument to enter the target concentration is provided. If this value is not zero, a horizontal line on the plots is shown in the
results page.
Please note: Any positive value other than '0.0' would display a horizontal target line in red. The units are same as plasma concentration and the units can be selected using the adjacent box.
✶ Concentration units
Two concentration units are provided in the model for display in plots and tables - mg/L (or) μg/mL and ng/mL. These units are reflected in plots and tables.
Human model only
✶ Clinical study year
The average population tends to vary every few years. Therefore, the model has an option to select the appropriate year during which the clinical study was performed. This way, the available population nearest to the study year is used for simulation. By default, the latest year is considered.
Animal models only
✶ Strain
An option has been provided to choose animal strains since the weights of the animals vary across strains. This would help the user to simulate the pharmacokinetics accordingly. Adjacent to the name of the strain, age range of the animal is provided which indicates the lower and higher limit of the age range to compute the weights accordingly. Any value out of the range will consider the lowest or the highest age provided to compute the weights.
✶ Age
Age of the animal affects the weight used in the model. Adjacent to each strain, the age range of the animal is provided to compute the weights accordingly. Any age out of the provided range with compute the weights with the lowest or the highest age from the given range.
Please note: Age of the animal should be provided in weeks.
✶ Scalars
The dose predictions are as good as the input data provided. Sometimes, the in vitro - in vivo extrapolations may not provide appropriate values which may result in difference between observed and simulated data. In these cases, some factors have to be adjusted such that the model simulation are closer to the observed data. An option to adjust the relevant parameters - absorption rate, tissue to plasma ratios (Distribution scalar, the same value is used to factor the tissue to plasma ratios of all organs and tissues) and clearance (apparent or intrinsic) using a scalar can be provided in the
boxes. Default is 1. These scalars multiply the relevant process(es) by the given value.
Please note: If any of the scalars are set to zero or less, the model would automatically set the values to 1 to avoid returning errors.