Teoreler Acknowledgements

A comprehensive whole-body Physiologically-Based Pharmacokinetic (PBPK) model serves as the foundation for intricate calculations. This model intricately accounts for the physiological intricacies of the entire body.
Teoreler incorporates a detailed representation of compartments, each reflecting specific physiological aspects. The structural framework of these compartments is elucidated to facilitate a nuanced understanding of the model's simulation dynamics in the figure below. This approach ensures a thorough exploration of pharmacokinetic processes, considering diverse bodily regions.

PBPK model

The utilization of a whole-body PBPK model not only enhances precision in computations but also enables a more accurate representation of the intricate interplay between drug dynamics and the multifaceted physiological environment. The current model has a few assumptions and limitations*:

  1. The oral model assumes complete drug dissolution in the stomach under fasted conditions.
  2. There is no reabsorption from the large intestine.
  3. The distribution model is blood flow limited.
  4. Organs/tissue compartments exhibit instantaneous and uniform drug distribution.
  5. First-order kinetics govern drug release from intramuscular and subcutaneous depot sites.
  6. The existing PBPK models consist of a human adult (18-60 years) model, a child/adolescent (2-18 years) model, an adult two-drug interaction model, a rat model, and a mouse model. These models are currently applicable for simulating drugs unaffected by transporters.

* - the models would be updated in the future to address the current limitations.