Population

The population characteristics used in the model are obtained from NHANES datasets from various years ranging from 1999 - 2018.¹ The age, weight and height of the individual are generated randomly. Based on the weight and height, BMI and BSA are computed. If the BMI is not in the acceptable range (i.e. <65 kg/m² for males, and <80 kg/m² for females, according to the NHAHES dataset), a new individual is generated until it satisfies that condition.

Organs and Tissues

The organ weights were computed using various anthropometric equations obtained from the literature.²The organ weights depend on the population characteristics - age, weight, height, bmi and bsa of the individual.
The organ volumes were computed using the organ weights and organ densities.

Blood flow

The cardiac output (Q_co) was computed from the weight of the individual³as represented by the following equation:

The blood flow rate to the individual organs was computed as a percentage of the cardiac output.³

References