Interface

This section enables a new user to understand the interface of Teoreler PBPK models and enables a new user to perform PBPK simulations for their drug of interest.

The interface looks as shown above for all the PBPK models on Teoreler. A concise interface has been presented where parameters have been categorized under various tabs to ease congestion on the screen. Description about each of the parameters of the PBPK model are described in additional sections displayed on the sidebar under 'PBPK Model'.

There are three ways to proceed with the execution of a simulation:

1. Preloaded drug profile:Teoreler has a list of compounds available in its library. Choosing a preloaded profile would update all the inputs with the appropriate values of the respective selection. In majority of cases, a validated model is presented for user convenience. The user can choose to simulate a population (maximum of 100) from the 'Characteristics' tab. Clicking on 'Simulate' button would present you the results. A list of observed data is also available in the 'Observed data' tab, where the user can overlay simulated and observed data in the plot section to the right.Please note:The drug profile library would be regularly updated. If the user want to contribute to this library, please use the Contact us section to write to us.
2. Input boxes:If the drug profile of interest is not available, the user can manually enter the parameters in the various input options provided to perform a simulation.If any parameter is invalid, the color of the 'Run simulation' button fades to grey and is inactive. Invalid boxes have a red border and a message is displayed under the box on why this value is invalid.Invalid Values: Once all values are valid, simulations can be run. Any changes made to the input boxes update the model summary section in real time. The values are reset to default when the user deletes the local storage values and refreshes the webpage again.
3. Upload drug profile: The user has an option to download a drug template from the 'Drug Profile' tab. The downloaded excel file can be edited by the user and this user edited template can be uploaded into the application. Once uploaded, the values from the excel sheet are automatically populated into the input boxes provided.Missing values: If there are any values missing for the parameters in the uploaded excel template, a default value is allocated to the missing parameter value.Invalid file: If the user uploads an invalid file, the values provided in the input boxes are used instead.