What is PBPK Modelling?
Physiologically Based Pharmacokinetic (PBPK) modelling is a computational approach used to predict the absorption, distribution, metabolism, and excretion of drugs in the human body by representing the body as a series of physiologically realistic compartments.
In PBPK modelling, each compartment corresponds to a specific organ or tissue such as the liver, kidneys, lungs, and brain, and is defined using anatomical, physiological, and biochemical parameters.
These models integrate drug-specific properties such as solubility, permeability, and enzyme kinetics with system-specific parameters like organ volumes, blood flow rates, and tissue composition to simulate drug concentration–time profiles in plasma and tissues.
PBPK models are mechanistic in nature, meaning they are based on biological principles rather than purely empirical data, which allows extrapolation across different populations, doses, and routes of administration.
- Prediction of pharmacokinetics in special populations such as pediatric, geriatric, or diseased patients
- Assessment of drug–drug interactions by modelling enzyme or transporter inhibition and induction
- Optimization of dose selection and dosing regimens
- Support of regulatory decision-making by agencies such as the FDA, EMA
Overall, PBPK modelling provides a powerful framework to link in vitro and in vivo data, reduce reliance on extensive clinical studies, and improve confidence in drug development and clinical pharmacology decisions.
More about the PBPK model used on Teoreler and the parameters used can be found in the PBPK Model section.