PBPK modelling - Human Child

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Model Parameters

Preloaded drug profile:

(or) enter values below (or)

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Log P:

Log P _vo:w:

Property:

pKa1:

pKa2:

pKa3:

Log D:

Protein binding :

Adult value

Blood-to-plasma ratio:

Adult value

Molecular weight:

Drug name:

Route of administration:

In vitro absorption type:

Absorption value:

x 10^-6cm/s x 10^-7cm/s

Polar surface area (Å²):

Hydrogen bond donors:

Computed Kₐ:

h⁻¹

Release rate (h⁻¹):

Infusion time (h):

Clearance type:

Clearance value:

Adult value

F_g value (if any) :

fu_{mic, gut}:

fu_{mic, liv}:

Enzyme 1:

Enzyme 1 value:

Enzyme 2:

Enzyme 2 value:

Enzyme 3:

Enzyme 3 value:

V_d method:

Renal clearance:

Adult value

Sex:

FemaleMaleBoth

Age range (years):

－

Population:

Dose:

Dosing interval:

Dose repeats:

Dose end time:

Simulation time:

Time units:

Lead Plot:

Lag time (in hours):

Target concentration:

Concentration units:

Clinical study year:

Absorption scalar:

Clearance scalar:

Distribution scalar:

Plasma profile :

Upload observed data:

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File name:

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Time units:

Concentration units: