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Home > PBPK models > Two-drug interaction model ^BETA

Model Parameters

Preloaded drug profile:

(or) enter values below (or)

Upload parameters

Log P:

Property:

pKa1, pKa2 (if any):

Protein binding (%):

Blood-to-plasma ratio:

Molecular weight:

Route of administration:

In vitro absorption type:

Absorption value:

x 10^-6

Release rate (h⁻¹):Infusion time (h):

Polar surface area (Å²):

Hydrogen bond donors:

Clearance type:

Enzyme:

Clearance value:

F value:

fu_gut:

fu_liv:

Enzyme 1:

Enzyme 1 value:

Enzyme 2:

Enzyme 2 value:

Enzyme 3:

Enzyme 3 value:

V_d method:

Renal clearance:

Induction 1 Enzyme:

Induction 1 type:

Induction 1 max:

Induction 1 IC₅₀:

Induction 1 k_deg:

..

Induction 2 Enzyme:

Induction 2 type:

Induction 2 max:

Induction 2 IC₅₀:

Induction 2 k_deg:

..

Induction 3 Enzyme:

Induction 3 type:

Induction 3 max:

Induction 3 IC₅₀:

Induction 3 k_deg:

Inhibition 1 Enzyme:

Inhibition 1 type:

Inhibition 1 K_i:

Inhibition 1 k_inact:

Inhibition 1 k_deg:

..

Inhibition 2 Enzyme:

Inhibition 2 type:

Inhibition 2 K_i:

Inhibition 2 k_inact:

Inhibition 2 k_deg:

..

Inhibition 3 Enzyme:

Inhibition 3 type:

Inhibition 3 K_i:

Inhibition 3 k_inact:

Inhibition 3 k_deg:

Sex:

FemaleMaleBoth

Dose:

Dosing interval:

Dose repeats:

Dose end time:

Simulation time:

Time units:

Population:

Target concentration:

Concentration units:

Clinical study year:

Absorption scalar:

Clearance scalar:

Distribution scalar:

Upload observed data:

Browse...

File name:

Remove file

Time units:

Concentration units:

Model Parameters

Preloaded drug profile:

(or) enter values below (or)

Upload parameters

Log P:

Property:

pKa1, pKa2 (if any):

Protein binding (%):

Blood-to-plasma ratio:

Molecular weight:

Route of administration:

In vitro absorption type:

Absorption value:

x 10^-6

Release rate (h⁻¹):Infusion time (h):

Polar surface area (Å²):

Hydrogen bond donors:

Clearance type:

Enzyme:

Clearance value:

F value:

fu_gut:

fu_liv:

Enzyme 1:

Enzyme 1 value:

Enzyme 2:

Enzyme 2 value:

Enzyme 3:

Enzyme 3 value:

V_d method:

Renal clearance:

Induction 1 Enzyme:

Induction 1 type:

Induction 1 max:

Induction 1 IC₅₀:

Induction 1 k_deg:

..

Induction 2 Enzyme:

Induction 2 type:

Induction 2 max:

Induction 2 IC₅₀:

Induction 2 k_deg:

..

Induction 3 Enzyme:

Induction 3 type:

Induction 3 max:

Induction 3 IC₅₀:

Induction 3 k_deg:

Inhibition 1 Enzyme:

Inhibition 1 type:

Inhibition 1 K_i:

Inhibition 1 k_inact:

Inhibition 1 k_deg:

..

Inhibition 2 Enzyme:

Inhibition 2 type:

Inhibition 2 K_i:

Inhibition 2 k_inact:

Inhibition 2 k_deg:

..

Inhibition 3 Enzyme:

Inhibition 3 type:

Inhibition 3 K_i:

Inhibition 3 k_inact:

Inhibition 1 k_deg:

Dose:

Dose start time:

Dosing interval:

Dose repeats:

Dose end time:

Target concentration:

Concentration units:

Absorption scalar:

Clearance scalar:

Distribution scalar:

Upload observed data:

Browse...

File name:

Remove file

Time units:

Concentration units: