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DDI (2 Drugs)
RAT
MOUSE
V
d
CALCULATOR
TEAM
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TEORELER
GET STARTED
PBPK PARAMETERS
PUBLICATIONS
PBPK MODELS
ALL MODELS
ADULT
DDI (2 Drugs)
RAT
MOUSE
V
d
CALCULATOR
TEAM
CONTACT US
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PBPK models
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Mouse
BETA
Model Parameters
Preloaded drug profile:
CUSTOM
---- Intramuscular -------
Atovaquone (IM)
---- Intravenous ---------
Atovaquone (IV)
(or) enter values below (or)
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Drug Inputs
ADME Inputs
Dose Inputs
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Log P:
Property:
Monoprotic acid
Monoprotic base
Diprotic base
Neutral
Zwitterion
pKa1, pKa2 (if any):
Protein binding (%):
Blood-to-plasma ratio:
Route of administration:
Oral
Intramuscular (IM)
Subcutaneous (SC)
Intravenous bolus (IV)
Infusion
In vitro
absorption type:
Apparent permeability - CACO-2 (⨯10⁻⁶ cm/s)
Apparent permeability - MDCK (⨯10⁻⁶ cm/s)
Polar Surface Area (PSA) (Ų)/ Hydrogen Bond Donors (HBD)
Absorption rate - Kₐ (h⁻¹)
Absorption value:
x 10
-6
Release rate (h⁻¹):
Infusion time (h):
Polar surface area (Ų):
Hydrogen bond donors:
Clearance type:
Apparent CL
Intrinsic
Clearance value:
L/h
L/h/kg
mL/min
mL/min/kg
F value:
Enzyme 1:
None
CYP2B10
CYP2C29
CYP2C38
CYP2C39
CYP2C55
CYP2D9
CYP2D10
CYP2E1
CYP3A25
UGT1A1
UGT1A2
UGT1A5
UGT1A6A
UGT1A9
UGT2A3
UGT2B1
UGT2B5
UGT2B34
UGT2B35
UGT2B36
Unknown
Enzyme 1 value:
µL/min/pmol
µL/min/mg
Enzyme 2:
None
CYP2B10
CYP2C29
CYP2C38
CYP2C39
CYP2C55
CYP2D9
CYP2D10
CYP2E1
CYP3A25
UGT1A1
UGT1A2
UGT1A5
UGT1A6A
UGT1A9
UGT2A3
UGT2B1
UGT2B5
UGT2B34
UGT2B35
UGT2B36
Unknown
Enzyme 2 value:
µL/min/pmol
µL/min/mg
Enzyme 3:
None
CYP2B10
CYP2C29
CYP2C38
CYP2C39
CYP2C55
CYP2D9
CYP2D10
CYP2E1
CYP3A25
UGT1A1
UGT1A2
UGT1A5
UGT1A6A
UGT1A9
UGT2A3
UGT2B1
UGT2B5
UGT2B34
UGT2B35
UGT2B36
Unknown
Enzyme 3 value:
µL/min/pmol
µL/min/mg
fu
gut
:
fu
liv
:
V
d
method:
Rodgers & Rowland
Poulin & Theil
Renal clearance:
L/h
L/h/kg
mL/min
mL/min/kg
mL/min/m²
Sex:
Female
Male
Both
Dose:
mg
µg
mg/kg
Dosing interval:
Dose repeats:
Dose end time:
Simulation time:
Time units:
Hours
Days
Weeks
Population:
Target concentration:
Concentration units:
mg/L (or) μg/mL
ng/mL
Animal strain:
C57BL/6 (3-24 weeks)
B6C3F1 (7-109 weeks)
FVB (4-16 weeks)
Animal age (in weeks):
Absorption scalar:
Clearance scalar:
Distribution scalar:
Upload observed data:
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File name:
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Time units:
Hours
Days
Weeks
Concentration units:
mg/L (or) μg/mL
ng/mL