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TEORELER
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GET STARTED
PBPK PARAMETERS
PUBLICATIONS
TUTORIAL
PBPK MODELS
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ADULT
CHILD
DDI (2 Drugs)
RAT
MOUSE
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Tissue-to-plasma ratios
Volume of distribution calculator
Preloaded drug profile:
CUSTOM
---- Human -------
Acebutolol-RS (adult)
Acetaminophen (adult)
Acetylcysteine (adult)
Acyclovir (adult)
Alfentanil (adult)
Alprazolam (adult)
Alprenolol (adult)
Amitriptyline (adult)
Amlodipine (adult)
Amobarbital (adult)
Amsacrine (adult)
Antipyrine (adult)
Aripiprazole (adult)
Ascorbic acid (adult)
Atenolol (adult)
Atropine (adult)
Betamethasone (adult)
Biperiden (adult)
Bumetanide (adult)
Bupivicaine (adult)
Cabotegravir (adult)
Caffeine (adult)
Captopril (adult)
Carvedilol (adult)
Cefiximine (adult)
Cerivastatin (adult)
Chloramphenicol (adult)
Chlordiazepoxide (adult)
Chlorpheniramine (adult)
Chlorpromazine (adult)
Cimetidine (adult)
Clomipramine (adult)
Clonazepam (adult)
Cloprednol (adult)
Clozapine (adult)
Cocaine (adult)
Colchicine (adult)
Coumarin (adult)
Cyclosphosphamide (adult)
Cyclosporin (adult)
Cytosine arabinoside (adult)
Desipramine (adult)
Dexamethasone (adult)
Diazepam (adult)
Dideoxyinosine (adult)
Digitoxin (adult)
Digoxin (adult)
Diltiazem (adult)
Diphenhydramine (adult)
Dipyridamole (adult)
Doxepin (adult)
Enprofylline (adult)
Entacapone (adult)
Epiroprim (adult)
Ergotamine (adult)
Estradiol (adult)
Ethambutol (adult)
Ethanol (adult)
Etidocaine (adult)
Etomidate (adult)
Famotidine (adult)
Felodipine (adult)
Fenoprofen (adult)
Fentanyl (adult)
Fluconazole (adult)
Fluvastatin (adult)
Furosemide (adult)
Gentamicin (adult)
Griseofluvin (adult)
Haloperidol (adult)
Hexobarbital (adult)
Hydrocortisone (adult)
Ibuprofen (adult)
Imipramine (adult)
Indomethacin (adult)
Isoniazid (adult)
Isosorbide dinitrate (adult)
Isosorbide mononitrate (adult)
Ketamine (adult)
Ketanserin (adult)
Ketorolac (adult)
Leuprolide (adult)
Lidocaine (adult)
Lorazepam (adult)
Lorcainide (adult)
Lormetazepam (adult)
Maprotiline (adult)
Meloxicam (adult)
Meperidine (adult)
Mepivacaine (adult)
Meptazinol (adult)
Metclopramide (adult)
Methadone (adult)
Methohexital (adult)
Methoxsalen (adult)
Methyprednisolone (adult)
Metolazone (adult)
Metoprolol-RS (adult)
Metronidazole (adult)
Mexiletine (adult)
Mibefradil (adult)
Midazolam (adult)
Morphine (adult)
Naloxone (adult)
Nicardipine (adult)
Nicoumalone-R (adult)
Nicoumalone-S (adult)
Nitrazepam (adult)
Nitrofurantoin (adult)
Nizatidine (adult)
Olanzapine (adult)
Omeprazole (adult)
Ondansetron (adult)
Oxazepam (adult)
Oxprenolol-RS (adult)
Paliperidone (adult)
Pentazocine (adult)
Pentobarbital (adult)
Pentoxifylline (adult)
Phenobarbital (adult)
Phenylbutazone (adult)
Phenytoin (adult)
Pindolol-RS (adult)
Prazosin (adult)
Prednisolone (adult)
Prednisone (adult)
Prilocaine (adult)
Procainamide (adult)
Promethazine (adult)
Propafenone (adult)
Propofol (adult)
Propranolol-RS (adult)
Quercetin (adult)
Quinidine (adult)
Remoxipride (adult)
Rilpivirine (adult)
Ropivacaine (adult)
Sematilide (adult)
Sildenafil (adult)
Sotalol (adult)
Sulpiride (adult)
Tenoxicam (adult)
Tetrahydrocannabinol (adult)
Theophylline (adult)
Thiopental (adult)
Thiopeta (adult)
Timolol (adult)
Tolamolol (adult)
Tolcapone (adult)
Tolfenamic acid (adult)
Toluene (adult)
Trazodone (adult)
Triazolam (adult)
Trimethoprim (adult)
Valproic acid (adult)
Verapamil (adult)
---- Rat -----------
2-Butanol (rat)
Acebutolol-R (rat)
Acebutolol-S (rat)
Acetaminophen (rat)
Acitretin (rat)
Afatinib (rat)
Alfentanil (rat)
Alprazolam (rat)
Amiodarone (rat)
Amlodipine (rat)
Amobarbital (rat)
Barbital (rat)
Betaxolol-R (rat)
Betaxolol-S (rat)
Biperiden (rat)
Bisoprolol-R (rat)
Bisoprolol-S (rat)
Bosutinib (rat)
Butyl (rat)
Butyl-ethyl-barbiturate (rat)
Carvedilol-R (rat)
Carvedilol-S (rat)
Cediranib (rat)
Cefazolin (rat)
Ceftazidime (rat)
Chlordiazepoxide (rat)
Chlorpromazine (rat)
Ciprofloxacin (rat)
Cocaine (rat)
Crizotinib (rat)
Cyclosporin (rat)
Dasatinib (rat)
Diazepam (rat)
Dideoxyinosine (rat)
Digoxin (rat)
Diltiazem (rat)
Disopyramide (rat)
Doxorubicin (rat)
Enoxacin (rat)
Epiroprim (rat)
Ethanol (rat)
Ethoxybenzamide (rat)
Ethyl (rat)
Ethylene glycol (rat)
Etomidate (rat)
Etretinate (rat)
Exaprolol (rat)
Fentanyl (rat)
Flunitrazepam (rat)
Ftorafur (rat)
Gefitinib (rat)
Heptyl (rat)
Heptyl-ethyl-barbiturate (rat)
Hexobarbital (rat)
Hexyl (rat)
Hexyl-ethyl-barbiturate (rat)
Imatinib (rat)
Imipramine (rat)
Inaperisone (rat)
Ketoprofen (rat)
Lapatinib (rat)
Lidocaine (rat)
Lomefloxacin (rat)
Masitinib (rat)
Mefloquine (S) (rat)
Mephenytoin (rat)
Methadone (rat)
Methyl (rat)
Methyl-ethyl-barbiturate (rat)
Methylphenidate (rat)
Metoprolol-R (rat)
Metoprolol-S (rat)
Midazolam (rat)
Naldixic acid (rat)
Nicotine (rat)
Nonyl (rat)
Nonyl-ethyl-barbiturate (rat)
Octyl (rat)
Octyl-ethyl-barbiturate (rat)
Ofloxacin (rat)
Oxazepam (rat)
Oxprenolol-R (rat)
Oxprenolol-S (rat)
Pefloxacin (rat)
Penicillin (rat)
Pentazocine (rat)
Pentobarbital (rat)
Pentyl (rat)
Pentyl-ethyl-barbiturate (rat)
Phencyclidine (rat)
Phenobarbital (rat)
Phenylbutazone (rat)
Phenytoin (rat)
Pindolol-R (rat)
Pindolol-S (rat)
Pipemedic acid (rat)
Prednisolone (rat)
Procainamide (rat)
Propafenone (rat)
Propranolol-R (rat)
Propranolol-S (rat)
Propyl (rat)
Propyl-ethyl-barbiturate (rat)
Quinidine (rat)
Remoxipride (rat)
Salicyclic acid (rat)
Saracatinib (rat)
Sunitinib (rat)
Tandutinib (rat)
t-Butyl Alcohol (rat)
Tenoxicam (rat)
Theophylline (rat)
Thiopental (rat)
Timolol (rat)
Tolbutamide (rat)
Triazolam (rat)
Valproic acid (rat)
Vandetanib (rat)
Verapamil (rat)
V
d
method:
Rodgers & Rowland - Schmitt
PK-Sim®
Schmitt W
Rodgers & Rowland
Berezhkovskiy
Poulin & Theil
Log P:
Log P
vo:w
:
Property:
Monoprotic acid
Monoprotic base
Diprotic acid
Diprotic base
Neutral
Zwitterion (pKa1 - Acid, pKa2 - Base)
Zwitterion (pKa1 - Acid, pKa2 - Acid, pKa3 - Base)
Zwitterion (pKa1 - Acid, pKa2 - Base, pKa3 - Base)
pKa1:
pKa2 :
pKa3:
Log D:
Protein binding :
Protein binding (%)
Fraction unbound
Blood-to-plasma ratio:
Species:
Human
Rat
Calculate on input change
