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DDI (2 Drugs)
RAT
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V
d
CALCULATOR
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Tissue-to-plasma ratios
Volume of distribution calculator
Preloaded drug profile:
CUSTOM
---- Human -------
Acebutolol-RS
Acetaminophen
Acetylcysteine
Acyclovir
Alfentanil
Alprazolam
Alprenolol
Amitriptyline
Amobarbital
Amlodipine
Amsacrine
Antipyrine
Ascorbic acid
Atenolol
Atropine
Betamethasone
Biperiden
Bumetanide
Bupivicaine
Caffeine
Captopril
Carvedilol
Cefiximine
Cerivastatin
Chloramphenicol
Chlordiazepoxide
Chlorpheniramine
Chlorpromazine
Cimetidine
Clomipramine
Clonazepam
Cloprednol
Clozapine
Cocaine
Colchicine
Coumarin
Cyclosphosphamide
Cyclosporin
Cytosine arabinoside
Desipramine
Dexamethasone
Diazepam
Dideoxyinosine
Digitoxin
Digoxin
Diltiazem
Diphenhydramine
Dipyridamole
Doxepin
Enprofylline
Entacapone
Epiroprim
Ergotamine
Estradiol
Ethambutol
Ethanol
Etidocaine
Etomidate
Famotidine
Felodipine
Fenoprofen
Fentanyl
Fluconazole
Fluvastatin
Furosemide
Gentamicin
Griseofluvin
Haloperidol
Hexobarbital
Hydrocortisone
Ibuprofen
Imipramine
Indomethacin
Isoniazid
Isosorbide dinitrate
Isosorbide mononitrate
Ketamine
Ketanserin
Ketorolac
Lidocaine
Lorazepam
Lorcainide
Lormetazepam
Maprotiline
Meloxicam
Meperidine
Mepivacaine
Meptazinol
Metclopramide
Methadone
Methohexital
Methoxsalen
Methyprednisolone
Metolazone
Metoprolol-RS
Metronidazole
Mexiletine
Mibefradil
Midazolam
Morphine
Naloxone
Nicardipine
Nicoumalone-R
Nicoumalone-S
Nitrazepam
Nitrofurantoin
Nizatidine
Omeprazole
Ondansetron
Oxazepam
Oxprenolol-RS
Pentazocine
Pentobarbital
Pentoxifylline
Phenobarbital
Phenylbutazone
Phenytoin
Pindolol-RS
Prazosin
Prednisolone
Prednisone
Prilocaine
Procainamide
Promethazine
Propafenone
Propofol
Propranolol-RS
Quercetin
Quinidine
Remoxipride
Ropivacaine
Sematilide
Sildenafil
Sotalol
Sulpiride
Tenoxicam
Tetrahydrocannabinol
Theophylline
Thiopental
Thiopeta
Timolol
Tolamolol
Tolcapone
Tolfenamic acid
Toluene
Trazodone
Triazolam
Trimethoprim
Valproic acid
Verapamil
---- Rat -----------
2-Butanol
Acebutolol-R
Acebutolol-S
Acetaminophen
Acitretin
Alfentanil
Alprazolam
Amiodarone
Amlodipine
Amobarbital
Barbital
Betaxolol-R
Betaxolol-S
Biperiden
Bisoprolol-R
Bisoprolol-S
Butyl
Butyl-ethyl-barbiturate
Carvedilol-R
Carvedilol-S
Cefazolin
Ceftazidime
Chlordiazepoxide
Chlorpromazine
Ciprofloxacin
Cocaine
Cyclosporin
Diazepam
Dideoxyinosine
Digoxin
Diltiazem
Disopyramide
Doxorubicin
Enoxacin
Epiroprim
Ethanol
Ethoxybenzamide
Ethyl
Ethylene glycol
Etomidate
Etretinate
Exaprolol
Fentanyl
Flunitrazepam
Ftorafur
Heptyl
Heptyl-ethyl-barbiturate
Hexobarbital
Hexyl
Hexyl-ethyl-barbiturate
Imipramine
Inaperisone
Ketoprofen
Lidocaine
Lomefloxacin
Mefloquine (S)
Mephenytoin
Methadone
Methyl
Methyl-ethyl-barbiturate
Methylphenidate
Metoprolol-R
Metoprolol-S
Midazolam
Naldixic acid
Nicotine
Nonyl
Nonyl-ethyl-barbiturate
Octyl
Octylethyl-barbiturate
Ofloxacin
Oxazepam
Oxprenolol-R
Oxprenolol-S
Pefloxacin
Penicillin
Pentazocine
Pentobarbital
Pentyl
Pentyl-ethyl-barbiturate
Phencyclidine
Phenobarbital
Phenylbutazone
Phenytoin
Pindolol-R
Pindolol-S
Pipemedic acid
Prednisolone
Procainamide
Propafenone
Propranolol-R
Propranolol-S
Propyl
Propylethyl-barbiturate
Quinidine
Remoxipride
Salicyclic acid
t-Butyl Alcohol
Tenoxicam
Theophylline
Thiopental
Timolol
Tolbutamide
Triazolam
Valproic acid
Verapamil
Drug Inputs
V
d
method:
Rodgers & Rowland
Poulin & Theil
Log P:
Log D (if any):
Property:
Monoprotic acid
Monoprotic base
Diprotic acid
Diprotic base (pKa1 >= pKa2)
Neutral
Zwitterion (pKa1 - Acid, pKa2 - Base)
Zwitterion (pKa1 - Acid, pKa2 - Acid, pKa3 - Base)
Zwitterion (pKa1 - Acid, pKa2 - Base, pKa3 - Base) (pKa2 >= pKa3)
pKa1:
pKa2 (if any):
pKa3 (if any):
Protein binding (%):
Blood-to-plasma ratio:
Species:
Human
Rat
